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Most Respected Viewers ! its all about the Types/ Risk / Factors / Symptoms / Screening Treatment & Prevention What Is Down Syndrome? Down syndrome (sometimes spelled “Down’s syndrome”) is a genetic abnormality. It is the most common single cause of birth defects in the United States This syndrome occurs because of an extra copy of chromosome 21. Your chromosomes contain your genetic material, & any problems with your chromosomes can cause serious physical and mental health problems Down syndrome causes lifelong developmental delays that can range from moderate to severe. It cannot be cured, but there are options. Down syndrome can be managed with educational interventions, specialized parenting techniques, and community engagement. These all can encourage a person with Down syndrome to develop life skills and social bonds, so that they can live a long (many Down syndrome patients live past the age of 50) and fulfilling life. Causes What Causes Down Syndrome? Down syndrome is e genetic disorder. TO understand how it happens, we first need to understand some basic genetics. In all cases of reproduction, both parents pass their genes on to their children. These genes are carried on chromosomes. When the baby’s cells develop, each cell is supposed to receive 23 pairs of chromosomes. Half of the chromosomes are from the mother and half from the father. In children with Down syndrome, one of the chromosomes does not separate properly. The baby ends up with three copies of chromosome 21 instead of two. This extra chromosome causes problems as the brain and physical features develop. Types Types of Down Syndrome There are three types of Down syndrome: Trisomy 21 Trisomy 21 means there is an extra copy of chromosome 21 in every cell. This is the most common form of Down syndrome. Mosaicism Mosaicism means there is an extra chromosome in some but not all of a child’s cells. Individuals with mosaic Down syndrome tend to have fewer symptoms. Translocation In this condition, children have only an extra part of chromosome 21. There are 46 total chromosomes. However, one of them has an extra piece of chromosome 21 attached. Risk Factors Will My Child Be at Risk for Down Syndrome? Certain parents have a greater risk of giving birth to a child with Down syndrome: women age 35 and older males 50 and older people with a family history of Down’s syndrome people who carry the genetic translocation Symptoms What Are the Symptoms of Down Syndrome? During pregnancy, there are no signs that a child will have Down syndrome. At birth, babies with Down syndrome usually have certain characteristic signs, including: flat facial features small head and ears short neck bulging tongue eyes that slant upward oddly shaped ears poor muscle tone A Down syndrome infant can be born a normal size. However development is twice as slow as for an unaffected child. There is usually some degree of mental retardation, but it is often mild to moderate. Mental and social development delays may mean that the child will have: impulsive behavior poor judgment short attention span slow learning capabilities Medical complications often accompany Down syndrome. These are caused by the extra chromosome. These may include: congenital heart defects hearing loss poor vision cataracts (clouded eyes) hip problems, such as dislocations leukemia chronic constipation sleep apnea (interrupted breathing during sleep) dementia (thought and memory problems) hypothyroidism (low thyroid function) obesity late tooth growth, causing problems with chewing Today, despite the medical and developmental delays, a child born with Down syndrome can live past the age of 50 (Mayo Clinic). Screening Screening for Down Syndrome During Pregnancy Screening is offered as a routine part of prenatal care in the United States. However, it is not required. First Trimester An ultrasound evaluation and blood tests can look for Down syndrome in your fetus. These tests are done between the 10th and 14th week of pregnancy. An ultrasound looks at the back of the baby’s neck, called the nuchal translucency. If there are problems with the baby’s development, more fluid collects in this area. Blood tests looks at the level of pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotropin (HCG). High levels of these proteins suggest a developmental problem. These tests have a higher false-positive rate than tests done at later pregnancy stages. If results are not normal, your doctor may follow up with an amniocentesis. In this test, an amniotic fluid sample is used to confirm the results. Second Trimester An ultrasound and quadruple marker screen (QMS) test can help identify Down syndrome and other neural tube defects. This test is done between 15 and 20 weeks. These tests measures four pregnancy-related factors: human chorionic gonadotropin (HCG) unconjugated estriol alpha-fetoprotein (AFP) inhibin-A If any of these tests are not normal, you will be considered at high risk for birth defects. Additional Prenatal Tests Your doctor may order additional tests to detect Down syndrome in your baby: amniocentesis: Your doctor takes a sample of amniotic fluid to examine the number of chromosomes the baby has. The test is usually done at 15 weeks. It carries a one in 200 miscarriage risk. chorionic villus sampling (CVS): Your doctor will take cells from your placenta to analyze fetal chromosomes. This test is done during the ninth and 14th week of pregnancy. It carries a miscarriage risk of one in 100. percutaneous umbilical blood sampling (PUBS): Your doctor will take blood from the umbilical cord and examine it for chromosomal defects. It is done after the 18th week of pregnancy. It carries an even higher rate of miscarriage, so it is performed only if all other tests are uncertain. Some women choose not to undergo these tests, because of the risk of miscarriage. They would rather risk having a child with Down syndrome than losing the pregnancy. Tests at Birth At birth, your doctor will: perform a physical examination of your baby order a blood test called a karyotype to confirm Down syndrome Treatment Treating Down Syndrome There is no cure for Down syndrome. However, parents can provide early intervention and opportunities to help their child with Down syndrome succeed. Early intervention programs promote a child’s learning. They offer the best chance for success. In these programs, special education teachers and therapists will help your child learn: sensory skills social skills self-help motor skills language and cognitive abilities Children with Down syndrome often meet age-related milestones. However, this may take up to two times longer than for other children. A team of physicians and specialists can help provide medical care and manage the medical complications. Because obesity can be particularly dangerous to the health of children with Down syndrome, it is important to encourage physical activity and avoid high-calorie foods. However, before beginning exercise or sports, the child’s hip, neck, and spine should be examined. It is important to teach children with Down syndrome about being independent and staying safe. Parents should establish a support network in the family and community. Learn as much as possible about your child’s condition. This can help you understand what it means as your child grows and develops. Many people with Down syndrome lead successful lives in their community. They often go to school, hold jobs, and become independent. Prevention Preventing Down Syndrome There is no way to prevent Down syndrome. You may want to speak with a genetic counselor: before having a child, to see if you are at risk if you already have a child with Down syndrome and are considering getting pregnant again Regards from' Oxfordcadets Team J Block Firdos Market Gulberg iii Lahore skype id oxfordcadets g mail oxfordcadets at g mail dot com whatsapp +92 333 4/6/3/3/9/9/0 Get Updates on + 92 342 37 2 5 129

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PPCS SERVICES We are introduce ourselves as the professionals in the field of Pest Control Industry of Pakistan. It is a long way (over two decades) before it reaches you so, be sure of its very high Quality and Warrantee Regarding our service, we can provide the ultimate solution of your pest problem with over 10 years of experience. We are providing Services are: Termite Proofing General Fumigation Cockroach Spray Jell Application for Cockroaches Anti Bedbugs Treatment Anti Wood Borer Treatment Mosquitoes Treatment Dengue Spray Fogging for Mosquitoes Ants Spray Pissu Treatment Snake Treatment Water Tank Cleaning etc. The egg-laying termite queen lays her eggs, the termite larvae transform into termite workers, termite soldiers or reproductive termites Dampwood termites like to live and feed in very moist wood. because they need lots of moisture, Dampwood Termites usually live in damp, dying wood or in houses with leaking plumbing that keeps the wood wet.Dampwood termites do not carry disease and don?t usually bother buildings because there is not enough water in the wood. Address: B-60, Akbar Paradise, Opp. Aladin Park, Main Rashid Minhas Road, Karachi. Website: www.ppcs.com.pk Call us Now !

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We are introduce ourselves as the professionals in the field of Pest Control Industry of Pakistan. It is a long way (over two decades) before it reaches you so, be sure of its very high Quality and Warrantee Regarding our service, we can provide the ultimate solution of your pest problem with over 10 years of experience. Termite Proofing Termite damages wood and losses are in billions of dollars per year. Termite is found in all structures build by human beings .They live underneath the soil and comes up in search of food .Wood is their favorite food. Termite damages all objects other than made-up of metal i.e. furniture ,fixture, carpets, currency, documents, cloths etc. There are two kinds of termite proofing:- Post Construction Termite Proofing Pre Construction Termite Proofing Regard, Perfect Pest Control Service

Termite Proofing Fumigation Services in Karachi. Perfect Pest Control: We are introduce ourselves as the professionals in the field of Pest Control Industry of Pakistan. It is a long way (over two decades) before it reaches you so, be sure of its very high Quality and Warrantee Regarding our service, we can provide the ultimate solution of your pest problem with over 10 years of experience. We Deals in: Termite Proofing General Fumigation Rodent Control Bedbugs Treatment Rodent Control Wood Borer Treatment Mosquitoes Spray Water Tank Cleaning Gel Application Etc. Termite Proofing: Termites feed on wood and anything that is made from wood, which includes cardboard boxes, paper products, lumber shipping pallets, your deck, wood fencing, wood fence posts, building beams, stacked cordwood used in fireplaces and flooring. Each termite colony ranges from 20,000 termites to five million. The worker termites are the ones that will damage your home, as they construct the colony's tunnels and gather food. If you disturb a colony, you'll usually see soldier termites first, which defend the colony. The queen termite lays eggs constantly and may live up to 20 years. Address: B-60, Akbar Paradise, Opp. Aladin Park, Main Rashid Minhas Road, Karachi. Call us For Free Survey. Note: We are also Available on Sunday. Website: www.ppcs.com.pk

We are introduce ourselves as the professionals in the field of Pest Control Industry of Pakistan. It is a long way (over two decades) before it reaches you so, be sure of its very high Quality and Warrantee Regarding our service, we can provide the ultimate solution of your pest problem with over 10 years of experience. We are Providing Fumigation Services in Homes, Flats, Banglows, Factories, Warehouses, Offices & Godon Etc. Our Services are: 1. Termite Proofing 2. General Fumigation 3. Bedbugs Treatment, 4. Rodent Control 5. Wood Borer Treatment 6. Cockroach Treatment 7. Mosquitoes Treatment 8. Water Tank Cleaning Etc. Eastern Subterranean Termites Termites are subterranean in nature, meaning they live and spend their life underground. They are very susceptible to natural enemies (like ants) and desiccation - so they need a constant source of moisture. They prefer to remain hidden so they often feed on wood that is in direct contact with the ground. A tell-tale sign of termites is straw shaped tunnels composed of sand or mud. This helps the termites stay protected and moist. One quick way to check for termites is by looking into the wooden framing in your basement. Any out of place mud or mud tubes will indicate termite activity. However, a house can be infested for years by the time a homeowner even notices. Because of their subterranean nature, they often eat wood from the inside out. If it's a sill plate or beam in your basement, significant damage can be done before it becomes visible. When a termite colony gets to be a certain size, it sends out winged termites whose sole purpose in life is to fly up, find a mate and start a new colony. In the spring we get a lot of calls where winged termites take over a person's basement. Termite swarmers differ from flying ants in that they have four wings of equal size--ant wings are two different sizes--and they have straight antennae and a wide waist. Termite swarmers may appear every year. Termite workers, however, are smaller, white and rarely seen. Damage from termites generally occurs in the recesses of the wood. Just prior to the adult stage, a termite can turn into any stage of termite: a worker, a soldier or a reproductive! A colony doesn't even need to send out "swarmers" to reproduce (swarmers are flying termites whose sole purpose is to find a mate and reproduce). Colonies can create "secondary reproductives" (reporductive termites without wings), which makes an infestation even more difficult to identify! Address: B-60, Akbar Paradise, Opp. Aladin Park, Main Rashid Minhas Road, Block- 10, Gulshan-e-Iqbal, Karachi, Pakistan. NOTE: Call us For Free Survey

Printing Press salutation Hope you will be safe and sound, May You Live Long. 1. Our Company is providing services since 2013. 2.Our customers are the reason for success. As a company our commitment has always been to satisfy our customers and to make excellent service a priority. Our commitment to competitive pricing. 3.Printing Advertising is recognized as a leader in the quick print and commercial print industry. We have all of the resources necessary to satisfy any of your printing or design needs. 4.Our goal is too constantly come up with innovative ways to make our clients look good on paper. Our design team is young and fresh with new ideas for today's consumer. As well, our equipment is constantly being upgraded to accommodate the latest in graphics design and making demands. 5.A well-executed printing campaign can bring Success to your business in a cost effective way. Printed materials can serve to reach many current and potential customers in a way that is unique and tangible. At Printing Advertising we help you reach these goals through our superior service and competitive pricing. 6.To serve customers with the highest quality graphic communication solutions and printed products produced precisely to their Requirements. 7.We establish and maintain Lifelong customer relationships through superior graphic communication services and printed products. We strive for excellence in all we do and treat everyone with dignity and respect. Printing Advertising mission is to provide excellent printing solutions to your company needs using state of the art technology. Printing Advertising aspires to provide the best, most efficient, and cost effective printing for your company. We are a leading printing supplier, printing manufacturers or printers of Poster, PVC Cards, flyers, leaflets, catalogues, corporate folders, paper bags, newsletters, annual reports, brochures, booklets, business cards, invoices, label stickers, letterheads, magazines, banners, pocket folders, greeting cards, calendars, envelopes, etc. Our team has many years of combined experience in the printing industry, enabling us to produce superior quality work. We specialize in fast turnaround without sacrificing quality. Our quality and unmatched pricing in Pakistan has earned us many satisfied return customers. We look forward to becoming your printer of choice

We are pleased to introduce ourselves as the professionals in the field of Pest Control Industry of Pakistan. History: It is a long way (over two decades) before it reaches you so, be sure of its very high Quality and Warrantee. Regarding our service, we can provide the ultimate solution of your pest problem with over 20 years of experience in product and quality assurance. Environment Friendly: Total Pest Control’s management and workers select to use Environment Friendly Products, which are used safely in residential, Commercial, industrial areas. We check that the product must be registered with EPA (Environmental Protection Agency). For further safety, wearing/using of Respirators, Gloves, Goggles Helmets etc are also practiced. Safety: The whole word is seriously considering protecting the new generation from forthcoming diseases and their causes. Therefor how we can ignore this hot issue. Our all operations are based on the authentic principal SAFETY FIRST. Before onset of any type of treatment / service, starting from selection of material upto the end of service, we consider all necessary measure to be adopted to avoid any accident. We put all the safety aspects before our working team and they are well equipped with almost all types of measure to adapt the safety. Marketing Team: A professional organization must have a team of officers / workers professionally sound. That’s why we have a group of qualified and well-experienced persons. Like: Entomologist, Plant pathologist and Marketing experts. We Deal in All Pest Control Services: Termite Treatment (pre & post construction) Bedbugs Treatment General Fumigation Water Tank Cleaning Wood-borer Treatment Lawn and Garden Spray Mosquitoes / Dengue Spray Cockroaches Control Treatment Rodent / Rats Control Treatment Flies and Ants Control Treatment COCKROACHES: A recent survey indicated that the cockroach was the most despised creature, beating out snakes, rats, bats, and spiders. The German cockroach or Blatella germanica is consider it to be a pest because it invades where we live, eat and sleep. Address: 4, Razzak Apartment, Opp. Askari Park, Main University Road, Karachi, Pakistan. Website: http://www.tpcs.com.pk

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We are happy to introduce ourselves as a Professionals in the field of Termite Control Management دیمک کنٹرول business in Punjab Pakistan. We've got (16) years of experience in Pest Control Management in Pakistan. In short, we've got what it takes to guard your home and business from even the foremost troublesome pests. Your pest control issues can before long be simply associate degree unpleasant memory. We offer Termite and Pest Control Services for Residential and Commercial jobs nationwide. We are in the business of making businesses better and homes safer by creating safer, healthier and more hygienic places to work and live. The cost of getting pest control wrong is one that businesses and homeowners can’t afford. The brand reputation of a business can be destroyed by one single pest issue, in one single site, anywhere in Pakistan. Someone’s home one of their biggest assets can be severely damaged or destroyed by pests. Hence the need for expertise, a promise which we are uniquely placed to deliver given our many decades of experience, market leadership and global backing. Every day we face new challenges. And every day we try to make our company standard more and more better. We give effective and affordable service for all pest issue. As well as written warranty against our service. We give proactive termite control pest control services to Residential, Commercial Houses, Flats, Portions, Apartment, Individual Villas, Beach Houses, Town House, Office, Factories, Colleges, Hostels, e.t.c. We have purely and minimum Odour Chemicals. Call us for free termite inspection